Baclofen in the treatment of persistent hiccup: a case series.
Int J Clin Pract. 2013 Jul 8;
Authors: Mirijello A, Addolorato G, D'Angelo C, Ferrulli A, Vassallo G, Antonelli M, Leggio L, Landolfi R
BACKGROUND: Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments.
AIM: To test baclofen administration for the treatment of persistent hiccup.
METHOD: We report a series of seven patients affected by persistent hiccup successfully treated with baclofen.
RESULTS: Hiccup stopped in all patients after a single administration of the drug.
CONCLUSIONS: Baclofen is a GABAB receptor agonist. It is conceivable that the reduction of dopamine release by GABAB receptor stimulation is able to interrupt hiccup's reflex arc.
PMID: 23834241 [PubMed - as supplied by publisher]