Functional Range of Creatinine Clearance for Renal Drug Dosing: A Practical Solution to the Controversy of Which Weight to Use in the Cockcroft-Gault Equation (July/August).
Ann Pharmacother. 2013 Jun 11;
Authors: Brown DL, Masselink AJ, Lalla CD
OBJECTIVE:To describe a practical solution for addressing body weight when using the Cockcroft-Gault equation to determine drug dosing.DATA SOURCES:A literature search was conducted using PubMed MEDLINE (1980-April 2013) using creatinine clearance, Cockcroft and Gault, Cockcroft-Gault, body weight, and obesity as search terms. Reference citations from publications reviewed were included.STUDY SELECTION AND DATA EXTRACTION:All English-language articles identified by the search were reviewed. Studies comparing the accuracy and bias of the Cockcroft-Gault equation using a variety of body weight designations in adult populations were included in the analysis.DATA SYNTHESIS:Study RESULTS: We propose the use of a CrCl range for drug dosing purposes, with the lower boundary defined by using IBW in the Cockcroft-Gault equation and the upper boundary by using TBW.
PMID: 23757387 [PubMed - as supplied by publisher]