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Single versus combination antibiotic therapy in adults hospitalised with community acquired pneumonia.
Thorax. 2013 May;68(5):493-5
Authors: Rodrigo C, Mckeever TM, Woodhead M, Lim WS, British Thoracic Society
Abstract
The benefits of β-lactam/macrolide combination therapy over β-lactam therapy alone for the treatment of hospitalised community-acquired pneumonia (CAP) in relation to pneumonia severity are uncertain. We studied 5240 adults hospitalised with CAP from 72 secondary care trusts across England and Wales. The overall 30-day inpatient (IP) death rate was 24.4%. Combination therapy was prescribed in 3239 (61.8%) patients. In a multivariable model, combination therapy was significantly associated with lower 30-day IP death rate in patients with moderate-severity CAP (adjusted OR 0.54, 95% CI 0.41 to 0.72) and high-severity CAP (adjusted OR 0.76, 95% CI 0.60 to 0.96) but not low-severity CAP.
PMID: 23076390 [PubMed - indexed for MEDLINE]