Confirmation of the initial antiphospholipid antibody positivity depends on antiphospholipid antibody profile.
J Thromb Haemost. 2013 Apr 19;
Authors: Pengo V, Ruffatti A, Del Ross T, Tonello M, Cuffaro S, Hoxha A, Banzato A, Bison E, Denas G, Bracco A, Padayattil Jose S
BACKGROUND: The revised classification criteria for the antiphospholipid syndrome (APS) state that antiphospholipid (aPL) antibodies [Lupus Anticoagulant (LAC) and/or anticardiolipin (aCL) and/or anti β2-glycoprotein I (aβ2GPI) antibodies] should be detected on two or more occasions at least 12 weeks apart. Consequently, classification of patients risk and adequacy of treatment may be deferred by three months. OBJECTIVES: In order to early classify patients risk, we evaluated whether aPL positivity confirmation is related to aPL antibody profiles. PATIENTS AND METHODS: Consecutive patients referred to our Center initially positive to one or more tests exploring the presence of aPL were tested after 3 months. During a four-years period 225 patients were initially positive to one or more test and 161 were available for confirmation after 3 months. Patients were classified as triple positive (n=54: LAC+, aCL+, aβ2GPI+, same isotype), double positive (n=50: LAC-, aCL+, aβ2GPI+, same isotype) and single positive (n=53: LAC or aCL or aβ2GPI antibodies as the sole positive test). RESULTS: Among subjects with triple positivity at initial testing, 98% (53out of 54) had their aPL profile confirmed after 12 weeks. Double and single positivity groups had data confirmed in 42 of 50 (84%) and 23 of 57 (40%) subjects, respectively. CONCLUSIONS: Our results show that high risk subjects with triple positive aPL profiles are identified early at time of the initial screening tests. This article is protected by copyright. All rights reserved.
PMID: 23601766 [PubMed - as supplied by publisher]