What Is the Relevance of Antimicrobial Resistance on the Outcome of Community-Acquired Pneumonia Caused by Streptococcus pneumoniae? (Should Macrolide Monotherapy Be Used for Mild Pneumonia?).
Infect Dis Clin North Am. 2013 Mar;27(1):87-97
Authors: Low DE
Multidrug-resistant pneumococci continue to increase worldwide. Although there are still questions regarding the relevance of β-lactam resistance, the recommendation for the use of the macrolides as monotherapy for mild community-acquired pneumonia should be revisited in view of high rates of resistance, the association of clinical failures with low-level and high-level resistance, and the lack of clinical data to support their need for empirical therapy for the atypicals.
PMID: 23398867 [PubMed - in process]