A New Era for Treating Enterococcus Faecalis Endocarditis: Ampicillin plus Short-Course Gentamicin or Ampicillin plus Ceftriaxone; That is the Question!
Circulation. 2013 Mar 29;
Authors: Miro JM, Pericas JM, Del Rio A, on behalf of the Hospital Clinic Endocarditis Study Group
Enterococci are the third most common etiologic agent of infective endocarditis worldwide after staphylococci and streptococci and cause 10-15% of cases(1). Enterococcal infections are increasingly relevant, especially among the elderly and patients with comorbid conditions in the healthcare setting(2,3). Approximately 90% of cases of enterococcal endocarditis are caused by Enterococcus faecalis, with less than 5% caused by Enterococcus faecium(2,3). The morbidity and mortality of enterococcal endocarditis is high. The percentage of patients requiring cardiac surgery (42%) and the 1-year mortality rate (29%) have remained almost unchanged for the last 30 years, and recent data show that they may even be increasing(3).
PMID: 23543003 [PubMed - as supplied by publisher]