A New Approach to Classification of Disease Severity and Progression of Chronic Obstructive Pulmonary Disease.
Chest. 2013 Mar 7;
Authors: Mannino DM, Diaz-Guzman E, Pospisil J
ABSTRACT BACKGROUND: Most current classification schemes for chronic obstructive pulmonary disease (COPD) use lung function as the primary way to classify disease severity and monitor disease progression. This approach misses important components of the disease process. METHODS: We evaluated existing data to develop a classification scheme for COPD using measures beyond lung function, including respiratory symptoms, exacerbation history, quality of life assessment, comorbidity, and body mass index. We then applied this scheme to data from the Lung Health Study, calculating a score for study subjects in year 1 and year 5 of the study, along with the difference between year 1 and year 5. FINDINGS: We developed a 4 point scale ranging from 1.00 (mild) to 4.00 (very severe). In year 1 of the study, the mean COPD score was 1.76, in year 5 it was 1.82. The mean difference from year 1 to year 5 was an increase (worsening) of 0.06, and a range from -1.0 to 1.6. The COPD score at year 1, year 5, and the difference between these scores were all predictive of mortality at follow-up. For example, the 14.0% of subjects whose score improved by at least 0.25 between year 1 and 5 had decreased mortality compared to those with stable scores (between -0.25 and 0.25, hazard ratio 0.6, 95% confidence interval 0.4, 0.8). INTERPRETATION: A COPD severity score that includes components in addition to lung function and allows for both improvement and worsening of disease may provide additional guidance to COPD classification, management, and prognosis.
PMID: 23471264 [PubMed - as supplied by publisher]