Novel combinations of vancomycin plus ceftaroline or oxacillin against methicillin resistant vancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous VISA (hVISA).
Antimicrob Agents Chemother. 2013 Feb 19;
Authors: Werth BJ, Vidaillac C, Murray KP, Newton KL, Sakoulas G, Nonejuie P, Pogliano J, Rybak MJ
Abstract
We demonstrated a significant inverse correlation between vancomycin and beta-lactam susceptibility in vancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous VISA (hVISA) isolates. Using time kill assays, vancomycin plus oxacillin or ceftaroline was synergistic against 3/5 VISA and 1/5 hVISA or 5/5 VISA and 4/5 hVISA, respectively. Beta-lactam exposure reduced overall vancomycin-bodipy binding but may have improved vancomycin-cell wall interactions to improve vancomycin activity. Further research is warranted to elucidate the mechanism behind vancomycin and beta-lactam synergy.
PMID: 23422917 [PubMed - as supplied by publisher]