Both Fidaxomicin and Vancomycin Inhibit Outgrowth of Clostridium difficile Spores.
Antimicrob Agents Chemother. 2012 Nov 12;
Authors: Allen CA, Babakhani F, Sears P, Nguyen L, Sorg JA
Abstract
Fidaxomicin (FDX) is approved to treat Clostridium difficile associated diarrhea, and is superior to vancomycin in providing a sustained clinical response (cure without recurrence in the subsequent 25 days). Mechanism(s) behind the low recurrence rate of FDX-treated patients could be multifactorial. Here, we tested effects of FDX, its metabolite OP-1118, and vancomycin on spore germination and determined that none affected the initiation of spore germination but all inhibited outgrowth of vegetative cells from germinated spores.
PMID: 23147724 [PubMed - as supplied by publisher]