Metformin overdose: time to move on.
Crit Care. 2012 Oct 25;16(5):164
Authors: Orban JC, Fontaine E, Ichai C
Abstract
ABSTRACT: Does metformin-associated lactic acidosis really exist? Despite an old controversy, there is no doubt about it. But do we understand what is going on? Laboratory findings raised several hypotheses explaining the pathophysiology of this disease. The main cause could be an inhibition of either gluconeogenesis or mitochondrial respiratory chain complex I. From bench to bedside, one hypothesis is now confirmed in humans. Metformin poisoning involves, at least partially, a mitochondrial dysfunction.
PMID: 23110819 [PubMed - as supplied by publisher]