Mild hypoglycemia is independently associated with increased risk of mortality in patients with sepsis: a three-year retrospective observational study.
Crit Care. 2012 Oct 12;16(5):R189
Authors: Park S, Kim DG, Suh GY, Kang JG, Ju YS, Lee YJ, Park JY, Lee SW, Jung KS
ABSTRACT: INTRODUCTION: Mild hypoglycemia is associated with increased mortality in critically ill patients. However, data regarding the association between mild hypoglycemia and patient outcomes among patients with sepsis are limited. METHODS: Patients admitted to a medical intensive care unit (ICU) for sepsis, as defined by the Surviving Sepsis Campaign guidelines, during a three-year period were enrolled retrospectively. Data on blood glucose (BG) control parameters and patients outcomes were collected. The primary outcome was the relationship of mild hypoglycemia, defined as minimum BG 40-69 mg/dL during ICU stay, to hospital mortality, and the secondary outcomes were ICU-acquired complication rates, ICU and one-year mortality rates. A relationship between glucose variability (GV) and hypoglycemic events was also investigated. RESULTS: Three-hundred and thirteen consecutive patients with sepsis were enrolled (mean age, 71.8 +/- 11.3 years; male, n = 166; diabetics, n = 102). A total of 14,249 (5.6/day/patient) BG tests were performed, and 175 hypoglycemic events (spontaneous, 71; iatrogenic, 104) occurred in 80 (25.6%) patients during the ICU stay; severe hypoglycemia (minimum BG level < 40 mg/dL) occurred in 24 (7.7%) patients and mild hypoglycemia (minimum BG level 40-69 mg/dL) was found in 56 (17.9%) patients. The frequency of hypoglycemic events increased with higher GV, and patients with mild hypoglycemia had higher rates of ICU-acquired complications than did those with no hypoglycemia (renal, 36.2% vs. 15.6% [P = 0.003]; cardiac, 31.9% vs. 14.3% [P = 0.008]; hepatic, 34.0% vs. 18.2% [P = 0.024]; bacteremia, 14.9% vs. 4.5% [P = 0.021]). Multivariate analysis revealed that mild hypoglycemia was independently associated with increased hospital mortality (odds ratio [OR], 3.43; 95% confidence interval [CI], 1.51-7.82), and even a single event was an independent risk factor (OR, 2.98; 95% CI, 1.10-8.09). Kaplan-Meier analysis demonstrated that mild hypoglycemia was significantly associated with a lower one-year cumulative survival rate among patients with sepsis (P < 0.001). CONCLUSIONS: Mild hypoglycemia was associated with increased risk of hospital and one-year mortality, as well as the occurrence of ICU-acquired complications. Thus, physicians need to recognise the importance of mild hypoglycemia in patients with sepsis.
PMID: 23062226 [PubMed - as supplied by publisher]