N-terminal Pro-B-Type Natriuretic Peptide, Left Ventricular Mass, and Incident Heart Failure: The Multi-Ethnic Study of Atherosclerosis.
Circ Heart Fail. 2012 Oct 2;
Authors: Choi EY, Bahrami H, Wu CO, Greenland P, Cushman M, Daniels LB, Almeida AL, Yoneyama K, Opdahl A, Jain A, Criqui MH, Siscovick D, Darwin C, Maisel A, Bluemke DA, Lima JA
BACKGROUND: -Elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) is associated with clinically overt heart failure (HF). However, whether it provides additive prognostic information for incident HF beyond traditional risk factors and the left ventricular (LV) mass index among multi-ethnic asymptomatic individuals has not yet been determined. We studied the associations of plasma NT-proBNP and magnetic resonance imaging (MRI) defined LV mass index with incident HF in an asymptomatic multi-ethnic population. METHODS AND RESULTS: -A total of 5597 multiethnic participants without clinically-apparent cardiovascular disease underwent baseline measurement of NT-proBNP, and were followed for 5.5 ± 1.1 years. Among them, 4163 also underwent baseline cardiac MRI. During follow-up, 111 participants experienced incident HF. Higher NT-proBNP was significantly associated with incident HF, independent of baseline age, sex, ethnicity, systolic blood pressure, diabetes, smoking, estimated glomerular filtration rate, medications (anti-hypertensive and statin), LV mass index and interim myocardial infarction [HR 1.95 per 1 unit log NT-proBNP increment, 95% CI 1.54-2.46, p10%) =0.175, p=0.019; category-less NRI=0.561, phttp://www.clinicaltrials.gov. Unique identifier: NCT00005487.
PMID: 23032197 [PubMed - as supplied by publisher]