Pharmacologic agents for mucus clearance in bronchiectasis.
Clin Chest Med. 2012 Jun;33(2):363-70
Authors: Nair GB, Ilowite JS
There are no approved pharmacologic agents to enhance mucus clearance in non-cystic fibrosis (CF) bronchiectasis. Evidence supports the use of hyperosmolar agents in CF, and studies with inhaled mannitol and hypertonic saline are ongoing in bronchiectasis. N-acetylcysteine may act more as an antioxidant than a mucolytic in other lung diseases. Dornase ? is beneficial to patients with CF, but is not useful in patients with non-CF bronchiectasis. Mucokinetic agents such as ?-agonists have the potential to improve mucociliary clearance in normals and many disease states, but have not been adequately studied in patients with bronchiectasis.
PMID: 22640851 [PubMed - in process]