Optimal meropenem concentrations to treat multi-drug resistant Pseudomonas aeruginosa septic shock.
Antimicrob Agents Chemother. 2012 Jan 30;
Authors: Taccone FS, Cotton F, Roisin S, Vincent JL, Jacobs F
Abstract
A patient with septic shock due to extensively-drug resistant (XDR) Pseudomonas aeruginosa was cured by optimizing the meropenem (MEM) regimen to obtain at least 40% of the time between two administrations in which drug levels were four times above the minimal inhibitory concentration (MIC) of the pathogen. As standard drug dose did not achieve these optimal concentrations, MEM regimen was progressively increased up to 12g/day (3g q6h in 3-hour extended infusion), which eventually resulted in sepsis resolution. High MEM dosage may represent a valuable therapeutic option for infection due to MDR strains and drug monitoring would allow rapid regimen adjustment in clinical practice.
PMID: 22290984 [PubMed - as supplied by publisher]