Incidence of Acute Pancreatitis Does Not Increase during Oktoberfest, but is Higher than Previously Described in Germany.
Clin Gastroenterol Hepatol. 2011 Jun 29;
Authors: Phillip V, Huber W, Hagemes F, Lorenz S, Matheis U, Preinfalk S, Schuster T, Lippl F, Saugel B, Schmid RM
BACKGROUND & AIMS: Increased alcohol consumption can lead to acute pancreatitis (AP). We investigated whether the incidence of alcohol-induced AP increased during the Munich Oktoberfest in 2008, at which 6.6 million liters of beer were sold within 16 days. METHODS: We performed a multicenter, prospective study of 188 patients with AP (36.7% alcohol-induced, 34.6% biliary), treated at 27 hospitals in the greater area of Munich, Germany (2,970,000 inhabitants) during the 2008 Oktoberfest. Data were compared with that from 2, 18-day control periods. RESULTS: During the Oktoberfest, the overall incidence of AP was 42.8/100,000 person-years, which is 117% higher than previously reported. The incidence of alcoholic AP did not increase during the Oktoberfest, compared with control periods. Acute attacks of alcoholic pancreatitis (AAP) were independently associated with repeated episodes of AP (P=.001), high levels of chronic alcohol intake (P=.001), low body-mass index (BMI, P=.007), male gender (P=.033), and acute alcohol excess (P=.037). Biliary AP was associated with increased levels of alanine-aminotransferase and aspartate-aminotransferase (P=.003), old age (P=.014), and low levels of chronic alcohol intake (P=.032). Death (5/188 patients) was associated with baseline levels of blood urea nitrogen (BUN, receiver operating characteristic-area under the curve [ROC-AUC]=0.918), alkaline phosphatase (ROC-AUC=0.861), and C-reactive protein (ROC-AUC=0.855). CONCLUSION: The incidence of AP does not increase during the Oktoberfest, compared with other time periods; the incidence of AP in Munich is higher than previously described in Germany. AAP was associated with long-term, heavy alcohol exposure rather than short-term, excessive alcohol drinking. Levels of BUN were associated with mortality.
PMID: 21723238 [PubMed - as supplied by publisher]