Reversal of Overanticoagulation in Very Elderly Hospitalized Patients with an INR above 5.0: 24-Hour INR Response after Vitamin K Administration.
Am J Med. 2011 Jun;124(6):527-33
Authors: Pautas E, Peyron I, Bouhadiba S, Golmard JL, Gouronnec A, Oboa N, Siguret V, Gouin-Thibault I
Reversal of overanticoagulation to minimize the bleeding risk is important in elderly inpatients receiving vitamin K antagonist therapy. However, no study has specifically focused on this population. The objective of this study is to evaluate whether guidelines based on American College of Chest Physicians recommendations for the management of overanticoagulation (international normalized ratio [INR] ?5.0) can apply to elderly inpatients, and notably allow 24-hour INRs to return to the 1.8-3.2 range in this population. The influence of different factors on the vitamin K response also was evaluated.
PMID: 21605730 [PubMed - in process]