Opioid dose and drug-related mortality in patients with nonmalignant pain.
Arch Intern Med. 2011 Apr 11;171(7):686-91
Authors: Gomes T, Mamdani MM, Dhalla IA, Paterson JM, Juurlink DN
Opioids are widely prescribed for chronic nonmalignant pain, often at doses exceeding those recommended in clinical practice guidelines. However, the risk-benefit ratio of high-dose opioid therapy is not well characterized. The objective of this study was to characterize the relationship between opioid dose and opioid-related mortality.
PMID: 21482846 [PubMed - in process]