Antiphospholipid syndrome: laboratory detection, mechanisms of action and treatment.

Link to article at PubMed

Antiphospholipid syndrome: laboratory detection, mechanisms of action and treatment.

J Intern Med. 2011 Feb 15;

Authors: Tripodi A, de Groot PG, Pengo V

The antiphospholipid syndrome (APS) identifies a condition at increased risk of vascular occlusion and/or pregnancy complications. Patients are defined as having APS if they have at least one clinical (vascular occlusion and/or pregnancy complications) and one laboratory criterion at the same time. The laboratory criteria that define APS are repeated positivity (confirmed 12 weeks apart) for lupus anticoagulants and/or antibodies targeted against cardiolipin or ?2-glycoprotein I immobilized on solid surfaces. Over the years APS has attracted the interest of many medical specialties. The aim of this review is to provide an update on: (i) the laboratory criteria that determine the presence of APS; (ii) how the antibodies increase the risk of vascular occlusion and fetal loss; and (iii) the treatment of the related clinical events.

PMID: 21323768 [PubMed - as supplied by publisher]

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