Factor Xa inhibitors for acute coronary syndromes.
Cochrane Database Syst Rev. 2011;1:CD007038
Authors: Brito V, Ciapponi A, Kwong J
The activation of coagulation mechanisms plays a central role in the pathogenesis of acute coronary syndromes (ACS). Administration of unfractionated heparin (UFH) and low molecular weight heparins (LMWH), agents preventing the progression of thrombus formation, is a crucial therapeutic strategy. However, some limitations related to their use have recently stimulated the development of new synthetic agents.
PMID: 21249686 [PubMed - in process]