Increasing vancomycin serum trough concentrations and incidence of nephrotoxicity.
Am J Med. 2010 Dec;123(12):1143-9
Authors: Pritchard L, Baker C, Leggett J, Sehdev P, Brown A, Bayley KB
Conflicting evidence regarding the association of vancomycin serum concentrations with efficacy and toxicity has resulted in controversy regarding optimal target concentrations. Recent publications recommend attaining higher vancomycin trough concentrations of 15 to 20 mg/L for target infections, yet limited research is available assessing the correlation of vancomycin serum concentrations with toxicity. The aim of this study was to evaluate the association between vancomycin serum trough concentrations and nephrotoxicity.
PMID: 21183005 [PubMed - in process]