Dose Comparisons of Clopidogrel and Aspirin in Acute Coronary Syndromes.
N Engl J Med. 2010 Sep 2;363(10):930-942
In a 2-by-2 factorial trial, patients presenting with an acute coronary syndrome and referred for an invasive strategy were randomly assigned to clopidogrel at either a double or a standard loading dose and to aspirin at either a higher or a lower dose. At 30 days, there was no difference for either the clopidogrel or the aspirin dose comparison with respect to the primary outcome of cardiovascular death, myocardial infarction, or stroke.
PMID: 20818903 [PubMed - as supplied by publisher]