Safety of Proton Pump Inhibitor Exposure.
Gastroenterology. 2010 Aug 18;
Authors: Yang YX, Metz DC
Proton pump (H+/K+-ATPase) inhibitors (PPIs) are widely used to treat patients with acid-related disorders because they are generally perceived to be safe and effective. However, as with any pharmacological agent, they have the potential for side effects. Many studies have examined the side effects of long- or short-term PPI exposure. We review the mechanism of action of PPIs, focusing on recently released products that might have greater risks of adverse effects than older products because of increased potency and/or duration of action. We summarize the data available on the putative adverse effects of PPI therapy and propose guidelines for clinicians who prescribe these agents, to limit the potential for adverse outcomes in users of these effective therapeutic agents.
PMID: 20727892 [PubMed - as supplied by publisher]