Nonventilatory strategies for patients with life-threatening 2009 H1N1 influenza and severe respiratory failure.
Crit Care Med. 2009 Dec 23;
Authors: Napolitano LM, Park PK, Raghavendran K, Bartlett RH
Severe respiratory failure (including acute lung injury and acute respiratory distress syndrome) caused by 2009 H1N1 influenza infection has been reported worldwide. Refractory hypoxemia is a common finding in these patients and can be challenging to manage. This review focuses on nonventilatory strategies in the advanced treatment of severe respiratory failure and refractory hypoxemia such as that seen in patients with severe acute respiratory distress syndrome attributable to 2009 H1N1 influenza. Specific modalities covered include conservative fluid management, prone positioning, inhaled nitric oxide, and extracorporeal membrane oxygenation and life support. Pharmacologic strategies (including steroids) investigated for the treatment of severe respiratory failure are also reviewed.
PMID: 20035216 [PubMed - as supplied by publisher]