The changing face of febrile neutropenia-from monotherapy to moulds to mucositis. Why empirical therapy?
J Antimicrob Chemother. 2009 May;63 Suppl 1:i14-5
Authors: Klastersky J
Why empirical therapy? Because it works! Empirical antimicrobial therapy is a reasonable, pragmatic approach to limit the ominous threat of Gram-negative sepsis in febrile neutropenic cancer patients. Empirical treatment of occult fungal infection in patients with neutropenia and persistent fever, in spite of initial broad-spectrum antimicrobial coverage, is effective but the role of pre-emptive treatment remains to be established.
PMID: 19372173 [PubMed - indexed for MEDLINE]